Gastro-retentive floating drug delivery systems have emerged as an efficient means of enhancing the bioavailability and controlled delivery of many drugs. FDDS promises to be a potential approach for gastric retention. The purpose of writing this review on floating drug delivery systems (FDDS) is to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments in FDDS which includes- the approaches in designing of single-unit and multiple-unit floating systems, and their classification, formulation aspects and applications of these systems are also covered in detail. This review also summarizes the in vitro techniques and in vivo studies to evaluate the performance of floating drug delivery systems.
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